With everyone's futures secured, Tommy can kick back and enjoy retirement. Tommy and Charlie work together to thwart Benny and Rico and to prove Dick's innocence. With their heads not arriving at their intended destination, Benny and Rico head to Mexico to collect the heads themselves, with plans to kill Tommy if they don't cross the border. Meanwhile, Tommy works with Charlie's friends Ernie (David Spade) and Steve (Todd Louiso) to replace a head lost by Charlie. Charlie and his girlfriend, Laurie (Kristy Swanson), discover the swap and try to get rid of the bag, but Laurie's father Dick (George Hamilton) gets arrested due to his alleged association with heads. Unfortunately for Tommy, his bag full of heads gets switched with that of a bumbling medical student, Charlie (Andy Comeau), who is on his way to a Mexican vacation. Joe Pesci totes around the titular piece of luggage as Tommy Spinelli, who is hired by two hitmen, Benny (Joe Basile) and Rico (Anthony Mangano), to bring the heads to their boss as proof of a job well done. '8 Heads in a Duffel Bag' centers around, yes, eight severed heads in a duffel bag.
